Creating Barriers A New Role for Schwann Cells and Desert Hedgehog
نویسنده
چکیده
when it is ectopically expressed (Tanabe et al., 1998). of genes that are sufficient to promote acquisition of a Thus, in some contexts Hb9 is sufficient to promote particular cell identity. v-MN identity, making it a candidate v-MN selector gene in mice. Judith S. Eisen If HB9 acts as a selector between interneuron and Institute of Neuroscience MN identities, one would predict that absence of HB9 University of Oregon function would lead to loss of the MN identity and that Eugene, Oregon 97403 cells would become V2 interneurons instead. Thaler, Arber, and their colleagues used knockout strategies in
منابع مشابه
The role of the desert hedgehog signaling pathway during degeneration and regeneration of peripheral nerves
The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...
متن کاملThe role of the desert hedgehog signaling pathway during degeneration and regeneration of peripheral nerves
The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...
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We show that Schwann cell-derived Desert hedgehog (Dhh) signals the formation of the connective tissue sheath around peripheral nerves. mRNAs for dhh and its receptor patched (ptc) are expressed in Schwann cells and perineural mesenchyme, respectively. In dhh-/- mice, epineurial collagen is reduced, while the perineurium is thin and disorganized, has patchy basal lamina, and fails to express co...
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Schwann cells are the main glial cell type in the PNS. They develop along nerves during embryogenesis and rely on the HMG domain containing Sox10 transcription factor for specification, lineage progression, and terminal differentiation. Sox10 deletion in immature Schwann cells caused peripheral nerve defects in mice that were not restricted to this glial cell type, although expression in the ne...
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عنوان ژورنال:
- Neuron
دوره 23 شماره
صفحات -
تاریخ انتشار 1999